京都市立病院における 糖尿病性ケトアシドーシス治療プロトコール導入効果と安全性

Abstract

院内に糖尿病性ケトアシドーシス標準治療がなく離脱遷延や低カリウム血症が頻発したため，欧米ガイドラインを参考に診療プロトコールを導入し，その導入前後の効果と安全性を後方視的に検証した．離脱時間は若干の延長傾向を認めたものの，低カリウム血症や中心静脈カテーテル留置の頻度は減少を認めた．本プロトコールは一定の有効性と安全性を示唆するが，少数例のため症例蓄積による継続検証が必要である．

Due to the lack of a standardized in-hospital protocol for diabetic ketoacidosis (DKA), DKA resolution was delayed and hypokalemia occurred frequently at our hospital. A new clinical protocol, based on Western guidelines, was initiated to address these issues. We retrospectively evaluated the efficacy and safety of the protocol by comparing pre- and post-implementation patient data. While the time to DKA resolution was slightly prolonged after the implementation, the incidences of hypokalemia and central venous catheter placement were decreased. The protocol demonstrated reasonable efficacy and safety. However, due to small sample size, further validation with larger sample size is warranted.